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Replimune Group tanked after the FDA rejected its melanoma treatment for a second time

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Josh Giddey #3 of the Chicago Bulls grabs a rebound during the second half against the Detroit Pistons on October 22, 2025 at the United Center in Chicago, Illinois.

Goldman Sachs dipped despite delivering an earnings beat.

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Summary

The S&P 500, Nasdaq 100, and Russell 2000 managed a positive start to the week, shaking off a surge in the price of oil that was prompted by President Trump’s order to blockade the Strait of Hormuz after peace talks between the US and Iran over the weekend failed to deliver a deal. The president said in a Truth Social post that the US Navy would block “any and all Ships trying to enter, or leave, the Strait of Hormuz.” US Central Command later confirmed the blockade would begin Monday and that only vessels transiting the strait to and from Iranian ports would be impeded. On Monday morning at the White House, Trump said Iran had reached out to the US regarding a peace deal. Neoclouds CoreWeave, Nebius, IREN, Cipher Digital, and Applied Digital surged as Anthropic’s deals mean the scramble for compute rolls on.

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