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Accelerating the search for antimicrobial peptides with Google Antigravity

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Overview of the ProtNLM pipeline translating raw amino acid sequences into natural-language biological annotations for unreviewed UniProtKB/TrEMBL entries. The functional annotation scope of the system covers protein names, function comments, subcellular locations, and GO terms, in addition to keywo.

New antibiotics are urgently needed to help with rising levels of antimicrobial resistance, but searching for new therapeutics is often a slow, labor-intensive process.

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Summary

Pengfei Tian, Maxwell L. Google Antigravity provides an agentic science workbench that empowers biologists to discover, structurally evaluate, and prioritize promising targets quickly, compressing what used to be a fragmented search over multiple databases into a single session. This technical walkthrough shows how biologists used Google Antigravity to uncover a novel antimicrobial peptide candidate which has predicted activity against the pathogens involved in respiratory tract infections. Rising antimicrobial resistance is one of the most pressing global health crises of their time and could result in an estimated 10 million annual deaths globally by 2050.

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